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Douglas Paddon-Jones,
Melinda Sheffield-Moore,
Asle Aarsland,
Robert R. Wolfe, and
Arny A. Ferrando.
Departments of Surgery and Anesthesiology, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas
We sought to determine whether ingestion of a between-meal supplement
containing 30 g of carbohydrate and 15 g of essential amino
acids (CAA) altered the metabolic response to a nutritionally
mixed meal in healthy, recreationally active male volunteers.
A control group (CON;
n = 6, 38 ± 8 yr, 86 ± 10
kg, 179 ± 3 cm) received a liquid mixed meal [protein,
23.4 ± 1.0 g (essential amino acids, 14.7 ± 0.7
g); carbohydrate, 126.6 ± 4.0 g; fat, 30.3 ± 2.8
g] every 5 h (0830, 1330, 1830). The experimental group (SUP;
n = 7, 36 ± 10 yr, 87 ± 12 kg, 180 ± 3
cm) consumed the same meals but, in addition, were given CAA
supplements (1100, 1600, 2100). Net phenylalanine balance (NB)
and fractional synthetic rate (FSR) were calculated during a
16-h primed constant infusion of
L-[
ring-
2H
5]phenylalanine.
Ingestion of a combination of CAA supplements and meals resulted
in a greater mixed muscle FSR than ingestion of the meals alone
(SUP, 0.099 ± 0.008; CON, 0.076 ± 0.005%/h;
P < 0.05). Both groups experienced an improvement in NB after
the morning (SUP, –2.2 ± 3.3; CON, –1.5 ±
3.5 nmol·min
–1·100 ml leg volume
–1)
and evening meals (SUP, –9.7 ± 4.3; CON, –6.7
± 4.1 nmol·min
–1·100 ml leg volume
–1).
NB after CAA ingestion was significantly greater than after
the meals, with values of 40.2 ± 8.5 nmol·min
–1·100
ml leg volume
–1. These data indicate that CAA supplementation
produces a greater anabolic effect than ingestion of intact
protein but does not interfere with the normal metabolic response
to a meal.
protein metabolism; diet; supplement; skeletal muscle
